Antibody directed enzyme prodrug therapy : Molecular studies on carboxypeptidase G2 , production by DNA shuffling of novel variants of CPG2 for more efficient cancer treatment

علاج مرض السرطان بإستخدام جسم مضاد موجه ومحمل بإنزيم الكربوكسى بيبتيديزجى2 : دراسات جزيئية على هذا الانزيم ، وانتاج مشابهات لهذا الانزيم ذو كفاءة اعلى من خلال تكنولوجيا قص وخلط وإعادة لصق الجين

Fatma Baiuomy Rashedy Abdallah

2010

Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry

Glucarpidase (former name : carboxypeptidase G2, or CPG2 ) is a bacterial enzyme that is widely used in detoxification of the cytotoxic drug methotrexate and in Antibody Directed Enzme Prodrug Therapy ( ADEPT ) for cancer treatment . In this study we report three achievements in relation to the CPG2 enzyme and the ADEPT for cancer treatment